The zebrafish heart regenerates after cryoinjury-induced myocardial infarction
نویسندگان
چکیده
منابع مشابه
Induction of Myocardial Infarction in Adult Zebrafish Using Cryoinjury
The mammalian heart is incapable of significant regeneration following an acute injury such as myocardial infarction(1). By contrast, urodele amphibians and teleost fish retain a remarkable capacity for cardiac regeneration with little or no scarring throughout life(2,3). It is not known why only some non-mammalian vertebrates can recreate a complete organ from remnant tissues(4,5). To understa...
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Translucent zebrafish larvae represent an established model to analyze genetics of cardiac development and human cardiac disease. More recently adult zebrafish are utilized to evaluate mechanisms of cardiac regeneration and by benefiting from recent genome editing technologies, including TALEN and CRISPR, adult zebrafish are emerging as a valuable in vivo model to evaluate novel disease genes a...
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Although fin regeneration following an amputation procedure has been well characterized, little is known about the impact of prolonged tissue damage on the execution of the regenerative programme in the zebrafish appendages. To induce histolytic processes in the caudal fin, we developed a new cryolesion model that combines the detrimental effects of freezing/thawing and ischemia. In contrast to...
متن کاملExtensive scar formation and regression during heart regeneration after cryoinjury in zebrafish.
The zebrafish heart has the capacity to regenerate after ventricular resection. Although this regeneration model has proved useful for the elucidation of certain regeneration mechanisms, it is based on the removal of heart tissue rather than its damage. Here, we characterize the cellular response and regenerative capacity of the zebrafish heart after cryoinjury, an alternative procedure that mo...
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Objectives: The primary purpose of this study was to determine the methods and means of prevention and treatment of coronary artery disease. In this study, we used a new regimen on heart rate and functional capacity of patients after myocardial infarction. This study also determines the effect of a new regimen on these factors. Methods: The cross sectional study was designed to assess the clin...
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ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2011
ISSN: 1471-213X
DOI: 10.1186/1471-213x-11-21